What We Do

Pharmaceutical Research

In Synovel Laboratory, we are experienced in drug discovery and development projects either in an early LI (Lead Identification) stage, late LO (Lead Optimization) stage or Pre-IND development stage.

We aim to provide the best drug candidate(s) for your project with the optimized potency; physical chemical properties (eg. aqueous solubility, solid crystallinity); DMPK properties (eg. human microsomal stability, animal in vivo PK) and toxicological liability (eg. CYPs inhibition and induction, hERG inhibition, cytotoxicity).

We provide the following services:

  • Custom Synthesis/ Fee-for-Service

  • Specific synthetic target by request

  • With or without established synthetic route

  • Rapid turnover time with low cost

Medicinal Chemistry Support (3C)

  • Consultation

  • Compound design (New lead identification, SAR exploration, Lead optimization)

  • Compound synthesis

  • Flexible payment schemes (Full time equivalent; Project based; Milestones based)

Process Chemistry Development Service

  • Synthetic routes optimization for lead candidates

  • Non-GMP grade intermediates syntheses

  • Exploratory salt screening

  • Isolation and syntheses of impurities according to CMC regulation for IND submission

Drug Discovery Support Services

  • Aqueous Solubility Analysis (Kinetic and Thermodynamic solubility)

  • Liver Microsomal Stability (human, mice, rat, monkey) Analysis

  • DMPK and Regulatory Services